AZD3839/ supplier with competitive price in stock-Rechems CAS NO.1227163-84-9

1.Custom synthetic service could be provided and COA/HPLC/HNMR is available.
2.Professional synthesis laboratory and production base.
3.Strong synthesis team and service team.
4.Professional data management system.
5.We provide the professional test date and product information.
6.Rich shipping methods,ex. Fedex,DHL,TNT,BY SEA and BY AIR.
7. We can accept various payment methods,Paypal,T/T, etc.
8.Professional packaging can be according the customers’requirment.

AZD3839 (free base) is a potent and selective BACE1 inhibitor with IC50 of 23.6 uM, about 14-fold selectivity over BACE2, also a β-secretase enzyme inhibitor.target: BACE1, β-secretase enzyme IC50: 23.6 uM AZD3839 dissolved in 0.33% dimethylsulfoxide In vitro: AZD3839 and its metabolites M1 and M2 inhibited CYP3A4 in a reversible and an irreversible manner, which could affect not only the metabolism of other CYP3A4 substrates but also the metabolism of AZD3839 itself.In vivo: AZD3839 is dissolved in 0.3 M gluconic acid, adjusted to pH 3.Solutions of 0.75, 2.5, and 7.5 mg/ml are prepared and are administered orally by gavage at 2 ml/kg body weight at 1.5, 5, and 15 mg/kg (study 1) and 15 mg/kg (study 2).AZD3839 effectively reduces the levels of Aβ in brain, CSF, and plasma in several preclinical species.
Shanghai Rechem science Co., Ltd.
Rechemsis focus on R&D of new APIS, signal transduction inhibitors and pharmaceutical intermediates. We follow closely the industry trend, and the latest research achievements in life science area.
Rechems is located in the largest biomedical base in China--Shanghai and cooperatively established modern production base and laboratory in surrounding areas. We have built up a good relationship with many US / European / Japanese pharmaceutical companies to conduct chemical research and inventory trading in medicinal chemistry.
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