PFI-4/ supplier with competitive price in stock-Rechems CAS NO.900305-37-5

1.Custom synthetic service could be provided and COA/HPLC/HNMR is available.
2.Professional synthesis laboratory and production base.
3.Strong synthesis team and service team.
4.Professional data management system.
5.We provide the professional test date and product information.
6.Rich shipping methods,ex. Fedex,DHL,TNT,BY SEA and BY AIR.
7. We can accept various payment methods,Paypal,T/T, etc.
8.Professional packaging can be according the customers’requirment.

PFI-4 is a potent and selective and cell permeable BRPF1 bromodomain inhibitor (IC50 = 80 nM).Exhibits >100-fold selectivity for BRPF1 over a panel of other bromodomains including BRPF2 (BRD1), BRPF3 and BRD4.IC50 value: 80 nM Target: BRPF1 in vitro: Disrupts BRPF1 binding to histone H3.3.PFI-4 is a chemical probe that specifically binds to the bromodomain of BRPF1 with a Kd =13 nM as determined by ITC.It reduces recovery time in triple BRD cell construct in FRAP, inhibiting binding to tri-acetylated histone 4 (residues 1-21).It has much lower affinity for bromodomain 1 of BRD4 (Kd = >50 μM) and is selective for BRPF1 over BRPF2 and BRPF3.PFI-4 is potent in cells, with an IC50 value of 250 nM.
Shanghai Rechem science Co., Ltd.
Rechemsis focus on R&D of new APIS, signal transduction inhibitors and pharmaceutical intermediates. We follow closely the industry trend, and the latest research achievements in life science area.
Rechems is located in the largest biomedical base in China--Shanghai and cooperatively established modern production base and laboratory in surrounding areas. We have built up a good relationship with many US / European / Japanese pharmaceutical companies to conduct chemical research and inventory trading in medicinal chemistry.
Rechems's mission is to serve pharmaceutical community by providing excellent services and high-quality products in a timely manner.
Rechems's vision is to be recognized by our clients as one of the best suppliers of chemical products for our superior quality, efficient and cost-effective services.
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