Ascomycin;Immunomycin;FR-900520;FK520)/ supplier with competitive price in stock-Rechems CAS NO.104987-12-4

1.Custom synthetic service could be provided and COA/HPLC/HNMR is available.
2.Professional synthesis laboratory and production base.
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4.Professional data management system.
5.We provide the professional test date and product information.
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Ascomycin(Immunomycin, FR-900520, FK520) is an ethyl analog of tacrolimus (FK506) with strong immunosuppressant properties.IC50 Value: 0.55 nM Target: in vitro: When we used either CD4+CD8+ thymocytes or peripheral T cells activated by phorbol ester and ionomycin, the cell surface induction of CD5 was also partially blocked by CsA, FK-520 and rapamycin .Ascomycinalso had a 3-fold lower immunosuppressive potency in a popliteal lymph node hyperplasia assay, resulting in an equivalent therapeutic index consistent with a common mechanistic dependence on calcineurin inhibition .in vivo: In 14-day studies, nephrotoxicity was not induced by continuous i.p.infusion of ascomycin at 10 mg/kg/day or daily oral administration (up to 50 mg/kg/day) in rats on a normal diet, nor by continuous i.v.infusion (up to 6 mg/kg/day) in rats on a low salt diet to enhance susceptibility .
Shanghai Rechem science Co., Ltd.
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