Setipiprant;ACT-129968;KYTH-105/ supplier with competitive price in stock-Rechems CAS NO.866460-33-5

1.Custom synthetic service could be provided and COA/HPLC/HNMR is available.
2.Professional synthesis laboratory and production base.
3.Strong synthesis team and service team.
4.Professional data management system.
5.We provide the professional test date and product information.
6.Rich shipping methods,ex. Fedex,DHL,TNT,BY SEA and BY AIR.
7. We can accept various payment methods,Paypal,T/T, etc.
8.Professional packaging can be according the customers’requirment.

Setipiprant is an orally available, selective CRTH2 antagonist.CRTH2 is a G protein-coupled receptor for PGD2.IC50 value: 6.0 nM Target: PGD2 in vitro: Setipiprant is an orally available, selective CRTH2 (chemoattractant receptor-homologous molecule expressed on T helper [Th]-2 cells) antagonist.CRTH2 is a G protein-coupled receptor for prostaglandin (PGD2).PGD2 is produced by the mast cells and is a key mediator in various inflammatory diseases, including allergy and asthma.Binding of PGD2 to CRTH2, which are expressed on the surface of blood-borne cells, induces chemotaxis of Th2 cells, basophils, and eosinophils, and stimulates cytokine release from these cells.Thus, antagonism of CRTH2 receptors is considered to be a promising therapeutic target for various allergic diseases and asthma.
Shanghai Rechem science Co., Ltd.
Rechemsis focus on R&D of new APIS, signal transduction inhibitors and pharmaceutical intermediates. We follow closely the industry trend, and the latest research achievements in life science area.
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